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Equine Infectious Anemia: Why do we test and why should you care?

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What is a Coggins test, and why is it so important? Why do I need a Coggins test if I am moving my horse(s) out of state or to an event? Why is the test only good for one year? This article will discuss the history of Equine Infectious Anemia and why it is a very important disease to keep under control. It will also discuss the route of transmission from one horse to another and the symptoms that a horse will have if it gets the disease.

Equine Infectious Anemia has been known by many names: Swamp Fever, Slow Fever, Mountain Fever, Equine Malarial Fever, and Coggins Disease, or EIA. It is a lentivirus from the family Retroviridae, and can infect all members of the Equidae family from ponies, donkeys, mules, and horses. EIA has been recognized as a disease of horses for centuries, but it made its big emergence in the 1930s and reached its height of devastation between the 1960s and 1970s. More than 10,000 horses were identified to be infected in 1975, and many of those horses died from the disease. Today the disease is less prevalent, and horses that do have the disease are nearly all-asymptomatic carriers of the disease, showing no signs of the disease. These horses act as reservoirs of the disease to spread to others.

The most common transmitting vector for EIA is biting flies, most commonly horse flies or deer flies. These flies lacerate the skin of horses to suck up a blood meal. The blood of an infected horse will remain on the mouth parts of these flies for a short period of time but long enough to be transmitted to an uninfected horse. Other ways of transmission is sharing hypodermic needles between horses, and it has even been found to be transmitted from mare to foal in utero.  Other minor routes of transmission can be from semen, milk and possibly be aerosolization of infectious material.

The clinical signs or symptoms of EIA are often nonspecific and usually the only sign is a fever. In severe cases horses will become weak, depressed, have increase heart rate and respiration rate, ventral edema, anemia, and bleeding from nostrils, and blood in their stools. Some cases will die during the acute phase of the disease, but those that recover will become asymptomatic persistently infected carriers. EIA is difficult to differentiate from other fever-producing diseases such as anthrax, influenza and equine encephalitis.

There is no treatment and no vaccines for EIA. The viral genome of EIA rapidly mutates, making it very difficult to create an effective vaccine to EIA.  Once a horse contracts EIA, the horse will always have the disease.

The only method to stop the spread of the disease is by prevention, and the only options to manage infected horses are to quarantine the infected horses at least 200 yards from healthy horses or to euthanize them. That is why testing is key to controlling the spread of this disease. Coggins testing is required once or twice a year depending on the state you live in, before traveling out of state, before entering an organized event, or sale of horses. It is always recommended to get a negative Coggins test before you introduce a new horse into a herd setting to maintain an EIA-free herd.

The Coggins test, developed in 1973 by Dr. Leroy Coggins, a graduate of Oklahoma State College of Veterinary Medicine in 1957, helps detect infected horses with EIA using the AGID method, or Agar Gel Immunodiffusion Assay. Dr. Coggins developed this test while studying viruses at Cornell University.  Today, the AGID test has been replaced mostly by the ELISA method. which is the most common test, used in reference labs around the country. The original method of testing of AGID is still considered the “gold standard” internationally.

If a horse is moved internationally they are required to get a Coggins test with the AGID method. A negative Coggins test is required before a health certificate is issued for travel. Generally most states require a negative Coggins test within one year, but some require it every six months. Veterinarians accredited by the USDA are the only veterinarians allowed to do Coggins testing and issue health certificates. Health certificates are issued to insure the horses that are traveling to events or crossing state lines are healthy and allow a level of traceability if a horse does become sick.  Most health certificates are issued for 30 days, but some are only issued for 10 days. A Coggins test requires hand drawn or digital images of your horse, identifying markings, address the horse resides, breed, age, sex, and owner’s information to complete the test. Today with a service called GlobalVetLINK hand drawn images are replaced with digital images uploaded into the Coggins form.

Luckily, with lots of hard work on behalf of veterinarians, laboratories, and state officials and due diligent horse owners, EIA is rather under control today, but there are still new cases of EIA discovered routinely. Also, there are many horses that do not receive testing, leading to possible reservoir of horses asymptomatically carrying EIA. Remember, even though it is sometimes inconvenient to get your horse’s Coggins test performed, you are doing your part to help control and prevent the spread of this terrible and incurable disease.

Read more great stories in the April 2020 issue of Oklahoma Farm & Ranch.

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Equine

Degenerative Suspensory Ligament Desmitis of the Horse

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By Dr. Garrett Metcalf

The suspensory ligament is a vital component of the limb of a horse to produce normal locomotion and support. The suspensory ligament is a common area of concern in performance horses of various disciplines and can be single handedly the cause of lameness or performance issues. This article is going to look at a specific degenerative disease of the suspensory ligament and what horses are at risk for this disease.

DSLD or degenerative suspensory ligament desmitis was first discovered in the early 1980’s in Peruvian Paso horses. The name has been changed because the suspensory ligament is not the only organ affected from the disease but the suspensory is ultimately the biggest issue. The newer name, ESPA or equine systemic proteoglycan accumulation, is more correct because other ligaments and tissues are affected by this disease. In this article we will only focus on the suspensory ligament. The most commonly affected breeds are Peruvian Paso, Paso Fino, Morgan, Saddlebred, Warmblood, Paints, American Quarter Horse, and Thoroughbred breeds. The age of onset of the disease is variable among breeds but it is more common to be seen in middle age to older horses.  However it has been documented in horses as young as one year of age. The disease generally will have a slow insidious onset that can go undiagnosed for months or years depending on the horses work and discipline.

A horse that begins to show early signs of DSLD may have a vague lameness issue that is difficult to isolate and they most likely will resolve with a period of rest. As the horse returns to moderate level of work the lameness will return. This scenario may go on for several months or more before the discovery of the DSLD is made. The first indication of DSLD is often pain isolated in the suspensory branches or fetlock region when a flexion test is performed. Horses with DSLD will also have a “dropped” fetlock appearance because the suspensory is the main supporting structure of the fetlock joint.  DSLD can affect the hind limbs, forelimbs or all limbs at the same time. A unique sign of DSLD is that not just one limb is affected but rather bilaterally affecting the limbs, meaning it will either affect either both forelimbs or hind limbs at the same time. It is my experience that the hind limbs are more commonly affected compared to the forelimbs. Horses will often have enlargement of the fetlock region and increased joint fluid or wind puffs. Horses will often have a straight hock or post legged hind limb appearance. Horses will often shift weight frequently in an effort to get relief from the discomfort and this can be confused with other lameness issues or foot related pain.

Diagnosis of DSLD is often made by clinical signs, breed and ultrasound findings. Ultrasound imaging of the suspensory ligaments will often show diffuse enlargement of the suspensory body and branches. The suspensory ligament will have a poor heterogeneous fiber pattern with periligamentious soft issue thickening from scar tissue deposition and edema or fluid within the tissue.  Radiographs of the lower limb may reveal abnormal bone changes in the sesamoid bones behind the fetlock joints and even osteoarthritis of the pastern and or fetlock joints. A definitive diagnosis can be made from a biopsy of a ligament in the neck called the nuchal ligament, but is not often performed because of the invasiveness of the biopsy.

Treatment is very limited and it is mostly geared towards protection of further damage by prolonged rest. Pain management is also important to attempt to keep the horse as comfortable as possible. Different shoeing techniques can be used with marginal success. In early cases of DSLD, a suspensory shoe that helps engage more work from the deep digital flexor tendon can help elevate the fetlock and offer more protection to the suspensory ligament. The devastating thing about this disease is that there is no cure and there are hardly any good options to slow the progression of the disease. DSLD carries a poor prognosis when the diagnosis is made in any breed of horse or any discipline. Although some cases can be managed better than others, it often progresses to the point of debilitating pain and discomfort to the point of humane euthanasia especially in the Peruvian Paso breed.

Read more in the February 2023 issue of Oklahoma Farm & Ranch.

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Equine

Gastric Ulcers

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By Dr. Devan England DVM

Does your horse have gastric ulcers? Gastric or stomach ulcers are frequently blamed for a variety of things including poor performance, acting ‘cinchy’, weight loss, not eating, poor coat condition, diarrhea and colic. However, gastric ulcers are not always the culprit and the only way to know for sure if your horse has gastric ulcers is to look at the stomach on camera, using an endoscope. Poor appetite and poor body condition are the mostly widely observed clinical signs with gastric ulcers, however, these are non-specific. If you think your horse might have gastric ulcers, the best place to start is to talk to your veterinarian and consider scheduling a gastroscopy. Gastroscopy requires the horse be held off feed for at least 16-18 hours and held off water for at least 6-8 hours. Fasting off feed and water is necessary to allow the veterinarian to see the whole stomach. If restricting feed or water is difficult in your management situation, many veterinarians will allow you to hospitalize your horse the night before gastroscopy for proper fasting.

Gastric ulcers are split into two types, classified by the location of the ulcer in the stomach. Squamous ulcers are ulcers that occur in the squamous or skin like portion of the stomach. This is the top part of the horse’s stomach, is closest to the esophagus, and has squamous tissue to protect this portion of the stomach from stomach acids. The other ulcer type are glandular ulcers. Glandular ulcers occur in the bottom portion of the stomach, which is closest to the small intestine. This portion of the stomach has glandular mucosa with cells responsible for producing stomach acids for digestion as well as cells that produce mucus and buffers to protect the lining from stomach acid. Gastroscopy is important not only for diagnosing whether ulcers are present but also determining the severity and the type of ulcer, because these two ulcer types require different treatments.

Squamous gastric ulcers are common in racehorses both in and out of training, with higher prevalence in racehorses under training. Prevalence in Thoroughbred racehorses in training has been reported to be up to 100% (Sykes 2015). Squamous ulcers are also prevalent in Western pleasure horses, Thoroughbred stallions on breeding farms, and Italian donkeys (Sykes 2015). Glandular gastric ulcer prevalence has not been as well described as squamous ulcers. Glandular ulcers are reported to be most common in Thoroughbred and Standardbred racehorses, Canadian showjumpers and polo ponies, and American Quarter Horses (Sykes 2015).

Risk factors for ulcers vary by ulcer type. Anti-inflammatories (Bute, Banamine) can increase the risk of glandular ulcers in some horses by affecting normal defense mechanisms but are not a high risk in most horses. Horses that display stereotypic behaviors, such as cribbing, have an increased risk of squamous ulcers. Grain fed before hay in non-exercising horses, feeding larger amounts of grain, and increased time between meals increases the risk of squamous ulcers. Increased time with high intensity exercise and housing in single pens is associated with increased risk of glandular ulcers. A straw only diet, lack of water access and lack of direct contact with other horses increases the general risk of gastric ulcers.

If your horse is diagnosed with ulcers, the mainstay of treatment is a buffered formulation of omeprazole (Gastrogard, Ulcergard). Over the counter Omeprazole and compounded Omeprazole are not effective because without buffering, the acidic stomach quickly breaks down the drug before absorption. Most horses with squamous ulcers will have healing of these ulcers after a 4-week course of Gastrogard or Ulcergard at treatment dose (whole tube for the average horse). Some horses may be healed by 3 weeks of treatment, but all horses should undergo a recheck gastroscopy before stopping treatment. Horses diagnosed with glandular ulcers need combination therapy with Gastrogard/Ulcergard and Sucralfate for 4 weeks. About 2/3 of horses with glandular ulcers will heal in this time, but some horses may require longer treatment times so a recheck is always recommended before discontinuing treatment.

Horses at higher risk of gastric ulcers may benefit from preventative (low) doses of Ulcergard (1/4 tube in average sized horse) given for a few days before and during high stress situations like long distance travel and competitions. Sea buckthorn berry supplement may be protective against formation of glandular ulcers. Dietary management to decrease the risk of ulcers includes providing more frequent small hay meals if pasture access is not available, limiting high sugar grains as much as possible and adding vegetable oil to the feed.

Sykes BW, Hewetson M, Hepburn RJ, Luthersson N, Tamzali Y. European college of equine internal medicine consensus statement – equine gastric ulcer syndrome in adult horses. J Vet Internal Med 2015; 29:1288-1299.

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Equine

Trailer Safety Checklist

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By Janis Blackwell

As the season arrives to gear up for participation in your equine event of choice, one thing remains a constant for all horse owners. That constant is our responsibility to insure the safety of our horses by being diligent to maintain the integrity of the trailers in which we haul them. There are a number of things that can be dangerous both inside and outside of your trailer. Whether you traveled all winter long or whether your trailer sat unused or was used very little through the cold weather months, at least once a year your trailer is due a thorough going over. So here we go with a checklist that will help you insure a happy and safe trip for you and your equine partner.

  1. A sound floor is absolutely imperative. Whether your floor is aluminum, steel or wood, it should be cleaned regularly after use to preserve it. Urine and manure will erode and weaken all types of floors. Even rubber mats will not prevent erosion of your floor. (Maintenance tip: remove mats and wash aluminum floors often to prevent erosion.)
  2. Especially check wooden floors for rotten boards. Immediately replace questionable flooring before hauling. (Maintenance tip: For wood, remove mats and wash out manure and debris. Coat wooden floor in a cheap motor oil. Allow to sit in hot summer weather until the oil soaks in. Be careful—floor will be slippery until oil cures into the wood. This treatment yearly will preserve a wooden floor for much longer than normal as it repels urine and protects the wood).
  1. Keep the interior and exterior washed to enable you to check for rusted out places, leaks, etc.
  2. Have a professional check your brakes at least once yearly to be sure they are operating properly.
  3. Be sure tires are inflated to the proper air pressure, and check the inside of each tire for hidden unusual wear that could cause a blowout. Replace worn tires before leaving home.
  4. Wheel bearings must be checked and packed at least once a year. This should be done even if the trailer has been rarely used since the last time the wheel bearings were packed. In fact, trailer maintenance professionals say that sitting stationary and unused is even worse for the bearings.  Improper care and maintenance of wheel bearings can cause a wheel to seize up and actually twist off while in use. Use a horse trailer professional for this maintenance task.
  5. Axles should be checked for bowing. A bent or bowed axle can cause excessive tire wear and damage wheel bearings.
  6. There should be no more than two inches in height difference from the front of the trailer to the back. More difference than that causes the bulk of weight of the trailer and its contents to ride mostly on the rear axle causing it to bow and wear on both tires and wheel bearings.
  7. Another critical part of the trailer to keep an eye on are the butt chain or bar and the back door. The butt chain or bar should be firmly attached to the wall and its keeper and should always be latched. The door should have a strong secure latch with a pin to insure it stays latched while in motion.
  8. Finally, but certainly not of least importance is a thorough check of the trailer hitch including ball and coupling. Keep the ball well greased. Periodically, check to see that the ball is still securely tightened and the latch on the coupling is working properly.

These few critical safety check points can save you money, stress and the wellbeing of your horse. Until next time, happy trails and safe traveling.

This article was originally published in the April 2016 issue of Oklahoma Farm & Ranch. 

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